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    Caroline has created a new way forward for existing drugs to be developed in rare diseases. She is accelerating the cost-effective development of unexplored therapeutic opportunities in rare diseases by addressing key translational gaps and clinical development challenges, acting as an investor, a patient voice integrator and a trusted broker between patients, pharmaceutical companies biomedical centers of expertise and regulatory authorities.

    Having secured the legal foundation for the human rights of the LGBT community through judicialization, Marinalva is now reinforcing mainstream support of the LGBT community in public life and at home.

    Poor children suffering from chronic illnesses in Philippine public hospitals experience extreme stress and pain. Families and hospital staff also suffer from the physical demands of caring and the emotional strain of treating children with serious, often terminal, conditions. Maria Fatima “Girlie” Lorenzo is transforming Philippine public hospitals by creating a national system for psychosocial support for indigent patients, their families, and caregivers.

    There are only 2,000 neurologists to deal with over a million aging people with cognitive diseases and no history of managed care in France, which leads to huge bottlenecks in the healthcare system and terrible social and psychological consequences for patients and their families.

    Judi Aubel is improving the lives of women, children and families by empowering grandmothers, an abundant and underutilized cultural resource, to catalyze change in socio-cultural norms related to many issues, including girls’ education, early and forced marriage, teen pregnancy, female genital mutilation, maternal and child health/nutrition and intergenerational communication.

    By teaching practical culinary and social skills, Simone Berti is preparing individuals with Down syndrome and other intellectual disabilities to assimilate into society and be self-sufficient.

    Anne Roos-Weil has piloted a cost-effective medical system to drastically reduce the number of African children and mothers who die from benign diseases. Combining simple skills and cell phones, she systematically collects basic health data and transfers it electronically to local medical staff to inform proper treatment or medical action.

    Dr. Roberto Kikawa has developed an affordable and sustainable system that is bringing teams of medical professionals to offer healthcare and health education services to low-income rural communities in Brazil.

    Jean-Loup Mouysset, trained as an oncologist, is revolutionizing the handling of chronic diseases by involving citizens in the process of follow-up and long-term support. The results of his pilot with cancer patients demonstrates the efficiency of his mindful community-based approach by influencing compliance to treatment, improving physical and psychological well-being, and reducing relapse and mortality rates.

    Grégory Gendre is building a new environmental paradigm by setting up a national network of professional and local recycling communities. Grégory has proven the economic and environmental efficiency of local waste management, from collection to treatment and production of added-value recycling products and services.